Transcutaneous Immunization Against Papillomavirus Disease
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This invention is a method of vaccinating against human papillomavirus (HPV) by using papillomavirus ?virus-like particles? transcutaneously to induce an immune response to the virus.
Papiloma viruses constitute a group of DNA viruses that induce both lytic infections and either benign or malignant tumors.
Papiloma viruses infect cutaneous, genital, oral, and respiratory epithelia in a tissue-specific manner. Infection with HPV has been associated closely with plantar warts, condylomata acuminata (anogenital warts), and premalignant and malignant lesions of the cervical squamous epithelium.
The ease of administration makes this useful for large-scale field administration, for use with pediatric or elderly patients as well as patients in Third-World populations.
Transcutaneous Immunization Against Papillomavirus with Papillomavirus Virus-like Particles
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