High Affinity Binding Proteins to Integrins

Brief Description
Applications:
This technology is related to the development of high affinity binding proteins to specific integrin proteins highly associated with cancer metastasis. Applications of these targeting molecules include tumor imaging, targeted tumor therapy, and targeted gene delivery.

Advantages:
These molecules are more stable, easier to make, and more amenable to protein engineering techniques than short peptides and antibodies.
Patent Information:
Title Country Patent No. Issued Date
avB3 Integrin-Binding Polypeptide Monobodies and Their Use United States 7,556,925 7/7/2009
Category(s):
Research Tools
For Information, Contact:
Matan Rapoport
Licensing Associate
University of Rochester
585.276.6600
matan.rapoport@rochester.edu
Inventors:
Shohei Koide
Stephen Dewhurst
Akiko Koide
Julie Richards Gunzler
Michelle Miller
Keywords:
Research Tool