The use of
patients own dendritic cells pulsed with a specific antigen to induce T-cells
responses and induction of memory T-cells is widely known as an approach for
stimulating the immune system in individualized medicine. This approach entails
isolation of monocytes from the blood (where their numbers are relatively low)
and their differentiation into dendritic cells over many days in cell culture.
Therefore, this process is labor intensive, requires large blood volumes and
makes contamination a potential major problem limiting the use of this approach
as common procedure in individualized medicine.
presents the platelets as a much better platform for this type of therapy. They
are very numerous in the blood and would not have to be differentiated and
cultured, limiting the time needed and the possibility of contamination.
useful vehicles to induce immune responses. One example is to use platelets to
induce or augment T-cell responses - this will be beneficial as a novel form of
vaccination or as a means to augment traditional vaccine
Platelets are much
easier to isolate then monocytes, are very numerous even in cases where a
patient is anemic or thrombocytopenic or otherwise has abnormal blood values,
the amount of blood needed would be minimal increasing the potential for