Inducing Immune Responses Using Platelets

Brief Description

Brief Description:

The use of patients own dendritic cells pulsed with a specific antigen to induce T-cells responses and induction of memory T-cells is widely known as an approach for stimulating the immune system in individualized medicine. This approach entails isolation of monocytes from the blood (where their numbers are relatively low) and their differentiation into dendritic cells over many days in cell culture. Therefore, this process is labor intensive, requires large blood volumes and makes contamination a potential major problem limiting the use of this approach as common procedure in individualized medicine.

This invention presents the platelets as a much better platform for this type of therapy. They are very numerous in the blood and would not have to be differentiated and cultured, limiting the time needed and the possibility of contamination.

Applications:

Platelets are useful vehicles to induce immune responses. One example is to use platelets to induce or augment T-cell responses - this will be beneficial as a novel form of vaccination or as a means to augment traditional vaccine responses.

Advantages:

Platelets are much easier to isolate then monocytes, are very numerous even in cases where a patient is anemic or thrombocytopenic or otherwise has abnormal blood values, the amount of blood needed would be minimal increasing the potential for individualized medicine.

 

 

Patent Information:
Title Country Patent No. Issued Date
Antigen Presenting Platelets and Methods of Eliciting an Immune Response United States 9,340,773 5/17/2016
Category(s):
Vaccines
Therapeutic
For Information, Contact:
Matan Rapoport
Licensing Associate
University of Rochester
585.276.6600
matan.rapoport@rochester.edu
Inventors:
Craig Morrell
Keywords:
Antibacterial
Antiviral
Cancer
Infection
Infectious Disease
Research Tool