Ultrasound Technology to Control the Spatial Organization of Cells and Proteins in Engineered Tissues

Brief Description

Applications: This technology provides a method for using ultrasound standing wave fields for the non-invasive control of the spatial organization of the cells and proteins during the fabrication of three-dimensional engineered tissues. The organization of the cells in the artificial tissues can regulate key cellular functions such as growth, migration and vessel formation. Additionally, the method allows for greater mechanical strength of the engineered tissue by organizing the cells and proteins into planar bands. These features may allow for the production of engineered tissues for many novel applications, including the production of tissue and organs needed for organ transplants.


Advantages: To produce functional artificial tissues and organs that can be used in transplants the tissues must be produced in vitro. This requires that essential nutrients and oxygen are delivered to the cells to uphold their metabolic processes. Current methods utilize passive diffusion of oxygen and nutrients through the tissue and host-dependent vascularization of the tissue after implantation. This, however, only works for tissue less than a few millimeters in volume. For engineering larger 3-D tissues a vascular system must be developed in vitro to provide the nutrients and oxygen to all regions of the tissue. By controlling the spatial organization through ultrasound standing wave fields vascularization within three dimensional engineered tissue constructs is possible, allowing the repair or production of larger 3-D tissues and organs.

Patent Information:
For Information, Contact:
John FahnerVihtelic
Senior Licensing Manager
University of Rochester
Diane Dalecki
Denise Hocking
Kelley Garvin