Brief Description:
This technology uses polarized light reflectance
interferometry for label-free detection of pathogens, monoclonal
antibodies, proteins and other target bio-molecules on a micro-array silicon
chip, with sensitivity similar to that of SPR and ELISA techiniques, but in
a low cost real-time system.
Applications:
This technology can be used for the
label-free detection of bio-molecules in several market
segments:
1. Measurement of biomolecular interactions in
research and drug discovery.
2. Point-or-care diagnostics in a physician's
office or remote clinic
3. Food safety, water safety and veteniary
medicine
4. Homeland security and military pathogen
detection.
Advantages:
The technique is sensitive to a 1 Angstrom layer of
absorbed bio-material.
Measurements can be made in real time in situ under
aqueous biological media.
The robust optics concept enables accurate measurements
on a chip array of 100 to 400 spots.
The concept can be extended to a low cost hand-held
detector for specific pathogen detection in the field.
Technology Status:
A prototype instrument is now being built for
biomolecular interaction analysis on a 100 spot array with automated fluid
handling and data analysis at 30 frames a
second.