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Septin inhibitors for treatment of cancer

Background Effective therapeutic options are limited for the treatment of liver, lung, renal, ovarian, endometrial and pancreatic cancer. Successive second- and third-line therapies do not add meaningful responses besides adding numerous life-debilitating toxicities. In order to improve the survival rate of patients diagnosed with these lethal malignancies,...

Published: 8/14/2023 | Inventor(s): Richard Moore, Rakesh Singh, Kyu Kwang Kim, Rachael Turner

Keywords(s):

Category(s): Therapeutic

Small molecule inhibitor of human epididymis protein 4 (HE4) for treating cancer

Background Epithelial ovarian cancer (EOC), is the fifth leading cause of cancer deaths in women, and the deadliest of all gynecologic cancers. The response of current chemotherapies has plateaued, creating a severe unmet need for superior therapies. Human epididymis protein 4 (HE4) is inordinately overexpressed in over 70% of EOC patients, acts...

Published: 8/14/2023 | Inventor(s): Richard Moore, Rakesh Singh, Kyu Kwang Kim

Keywords(s):

Category(s): Therapeutic

URML-3881, a Novel MEK Inhibitor for the Treatment of Cancers

Provided herein, are compounds, compositions, and methods of treatment of cancers using an inhibitor of MAPK/ERK Kinase (MEK), in particular hydrazine derivatives.

Published: 10/5/2023 | Inventor(s): Richard Moore, Rakesh Singh, Rachael Turner, Kyu Kwang Kim, Negar Khazan

Keywords(s):

Category(s): Therapeutic