technology presented here is a unique probe for the diagnosis of methicillin.
This probe represents an important step forward in researcher?s ability to
rapidly and effectively detect the presence of antibiotic resistance in
Applications: The DNA probes
described herein have a unique shape and sequence; these characteristics make
them highly complementary to their targeted gene sequences. This method, unlike
current techniques, allows for highly sensitive and specific DNA detections to
be made. This invention can be incorporated into diagnostic technologies for
rapid diagnosis of antibiotic resistance in common skin and systemic
aureus is one of the leading causes of human illness in the world.
Making matters worse, S. aureus has developed a remarkable ability to
resist the bacterial capabilities of many of the world?s leading
antibiotics. Using a previously
disclosed method of partial gene analysis ( Identification of Hairpin DNA probes
by Partial-Gene Folding ), the inventors have developed DNA probes that are
capable of detecting the presence of the mecR gene, a gene necessary for
methicillin resistance to be present in S. aureus.