Integrated Microfluidic Bubble Bioreactor for Cell Capture
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A lab-on-chip bioreactor for cell capture and analysis.
This invention describes a novel process to microfabricate perfectly spherical concave lab-on-a-chip bioreactors that can be used capture cells from steady flow and maintain them for basic research investigations and/or for use in medical diagnostics/treatment. One application has been to capture stem cells from peripheral blood and maintain them in the bubble bioreactors for further investigation.
Computational fluid dynamics (CFD) analysis indicates that these spherical bioreactors have unique flow properties that are sufficient to maintain viability of cells.
Microfluidic Device and Method of Manufacturing the Microfluidic Device
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Senior Licensing Manager
University of Rochester
Ut-Binh Thi Giang
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