RNA Modification to Modulate Telomerase Activity

Brief Description

Applications:

2?-O-methylation at U809 reduces telomerase activity resulting in telomere shortening, whereas 2?-O-methylation at A804 or A805 leads to moderate telomere lengthening.

 

Advantages:

Researchers at the University of Rochester have shown that the use of 2?-O-methylation can be accomplished in vivo and have an effect on telomerase activity.

Patent Information:
Title Country Patent No. Issued Date
Targeted 2'-O-Methylation of Telomerase Non-Coding RNA United States 9,273,294 3/1/2016
Category(s):
Therapeutic
For Information, Contact:
Weimin Kaufman
Licensing Manager
University of Rochester
585.276.6608
weimin.kaufman@rochester.edu
Inventors:
Yi-Tao Yu
Chao Huang
Keywords:
Cancer
Research Tool
RNA