A Cell Line Capable of Sensing HIF-1alpha Activation in the CNS for Use in Screening Pharmacologic Agents Capable of Activating/Attenuating Hypoxic Activated Gene Transcription
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This technology describes a stable reporter cell line that measures the expression of hypoxia-inducible-1-alpha (HIF-1a), a transcriptional activator, which is useful in screening compound libraries for anti-ischemic, neuroprotective and tumor pro-apoptotic activity. Drug candidates identified with this technology could potentially address therapies for central nervous system ischemia, cardiac ischemia, and cancer.
This cell lines offer a fast and economical tool to learn how drug leads can regulate pathologic hypoxia-dependent transcriptional processes such as: delayed neuronal death which occurs following CNS ischemia, myocyte death caused by recurrent myocardial ischemia, and hypoxic signaling which contributes to the progression of solid tumors.
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