Applications: Currently, large orthopedic fractures
(>3mm) presents a challenge clinically as proliferation of cells that
differentiate into osteochondral cell types is required to heal the fracture.
This technology provides a method, using a specific molecule, for inducing the
proliferation of human mesenchymal stem cells (hMSC) in vitro. This increased
proliferation has potential applications in regenerative medicine by providing a
means for the robust expansion of in vivo transplanted patient-specific stem
cells and providing homogeneous, multipotent cells for differentiation and
Advantages: Most current technologies that are
used to maintain stemness and enhance MSC proliferation rely on growth factors,
which are often variable and are expensive. This technology, instead, utilizes a
small molecule drug that is not variable and is inexpensive. Additionally, to
achieve proliferation and maintain stemness this technology only requires one
short (24h) dosage, whereas current strategies require long-term dosage.