Inhibition of Molecular Mediators in TNF-Signaling (Inflammation) for the Treatment of Cardiovascular Diseases Such as Atherosclerosis, Stroke, and Ischemia/Reperfusion Injury
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This technology has identified a molecular mediator of TNF-signaling and subsequent inflammation in endothelial cells. Pharmacological inhibition of this mediator can be beneficial for the treatment of cardiovascular diseases such as atherosclerosis, stroke, and ischemia/reperfusion injury.
This method for protecting against ischemia and reperfusion damage by inhibiting the interaction between thioredoxin and thioredoxin interacting protein allows increased thioredoxin activity which inhibits downstream events that can cause cardiovascular tissue damage.
Thioredoxin Interacting Protein (TXNIP) as a Regulator of Vascular Function
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