Human-Mouse Chimeric Model to Assess in vivo Response of Human Glial to Injury, Disease Perturbation, and Drug Treatment

Brief Description
Applications:
The invention has generated chimeric human-mouse brains in which the relative proportion of human astrocytes and oligodendrocytes is quite high, often exceeding 50% of all cells in the adult white matter. More over, researchers have established mice in which 100% of myelin, in substantially normal myelinated brain, is of human origin.

Advantages:
In vivo responses of human glia -including glial progenitor cells, astrocytes, and oligodendrocytes- to injury and disease states may be imaged and biochemically assessed, in a mouse model that permits disease perturbation, drug treatment, serial observation, sacrifice, and cell sorting.
 
URV Reference Number: 6-1569
Patent Information:
Title Country Patent No. Issued Date
Non-Human Animals With Human-Glial Chimeric Brains United States 7,524,491 4/28/2009
Category(s):
Research Tools
For Information, Contact:
Matan Rapoport
Licensing Associate
University of Rochester
585.276.6600
matan.rapoport@rochester.edu
Inventors:
Steven Goldman
Martha Windrem
Keywords:
Alzheimer's
in vivo
Mouse
Parkinson's
Research Tool
Stroke