Human-Mouse Chimeric Model to Assess in vivo Response of Human Glial to Injury, Disease Perturbation, and Drug Treatment
URV Reference Number:
The invention has generated chimeric human-mouse brains in which the relative proportion of human astrocytes and oligodendrocytes is quite high, often exceeding 50% of all cells in the adult white matter. More over, researchers have established mice in which 100% of myelin, in substantially normal myelinated brain, is of human origin.
responses of human glia -including glial progenitor cells, astrocytes, and oligodendrocytes- to injury and disease states may be imaged and biochemically assessed, in a mouse model that permits disease perturbation, drug treatment, serial observation, sacrifice, and cell sorting.
URV Reference Number: 6-1569
Non-Human Animals With Human-Glial Chimeric Brains
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