Method to Correct for Skeletal Lead Interference in Bone Mineral Density Measurements
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This technology describes a method to correct for the interference that lead levels in human bone have on diagnostic tests for osteoporosis. The presence of lead in bone creates an artifact in the accurate measurement of bone mineral density which is an important metric in the diagnosis for osteoporosis. Correction for this interference will alter clinical decision making as to whether patients commence therapy for osteoporosis.
The standard method to measure bone mineral density is DEXA (dual energy x-ray absorptiometry). Current DEXA measurement practice does not include any corrections for skeletal lead. The proposed algorithm for correcting DEXA measurements based on the amount of lead in the bone will prevent mis-diagnoses of osteoporosis.
Correction of Dual energy X-Ray Absorptiometry Measurements Base on Body Lead Levels
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Senior Licensing Manager
University of Rochester
J. Edward Puzas
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