Antigenic Mimics of Discontinuous HIV-1 Envelope Epitopes Recognized by Broadly Neutralizing Antibodies

Brief Description

The present invention describes an approach to identify antigenic mimics of conformational epitopes recognized by broadly neutralizing antibodies, including antibodies known to neutralize HIV-1.



The surface HIV -1 envelope glycoprotein subunit, gp 120, is a major target for virus-neutralizing antibodies, but immunization with recombinant gp 120 failed to elicit broadly neutralizing antibodies and has failed to demonstrate protective efficacy in a Phase III clinical trials.



The present invention relates to  polypeptides derived from the tenth fibronectin type III domain from human fibronectin ("FNfn 1 0"), fibronectin type III to generate antibodies (i) binding to a neutralizing monoclonal antibody reactive to HIV-1 or inducing a neutralizing immune response against HIV-1.

Patent Information:
Title Country Patent No. Issued Date
Antigenic Mimics of Discontinuous Epitopes of Pathogens Recognized by Broadly Neutralizing Antibodies United States 8,961,977 2/24/2015
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For Information, Contact:
Matan Rapoport
Licensing Associate
University of Rochester
Stephen Dewhurst
Mark Sullivan