Description: This invention
describes a methodology to improve the sensitivity of porous silicon optical
sensors that will enable point of care use in detection of
Applications: This sensor can be
designed to detect targets important in bioterrorism, environmental waste
management, drug discovery, narcotic substance abuse, protein detection in
biological samples (e.g. blood, urine, and saliva), and detection of gaseous
targets can also be made possible.
Advantages: The increasing need
for rapid and portable biosensor technology is evidenced by the growing
worldwide markets for environmental field testing (FT) and point-of-care (POC)
biomedical diagnostic markets, the latter with obvious applications in home
health testing (e.g. cholesterol, pregnancy, etc.), drug screening (e.g. sports,
clinics, sobriety check points, etc.), and pathogen surveillance for military,
homeland security and public health testing. A successful FT/POC platform
technology will, in addition to speed, sensitivity and accuracy, be inexpensive
and not require extensive training or sophisticated instrumentation for readout.
There are many advantages of porous silicon technology for FT/POC sensing
applications including inexpensive fabrication, precise control of pore
morphology, intrinsic filtering properties, high surface area, versatile surface
chemistry, capacity for label-free colorimetric readout, and compatibility with
high throughput array and microfluidic technologies. This technology maps out
the creation of such a device and explains the proper way in which to use it.